Recent studies reveal that cannabis consumption can potentially alter sperm DNA, affecting fertility, offspring health, and long-term neurological development.
Rising Cannabis Use and Health Concerns
With global legalization trends, cannabis use is becoming increasingly common among men of reproductive age. A 2015 survey reported that over 52% of men had used cannabis at some point. While cannabis offers therapeutic benefits, researchers warn about potential risks, especially concerning reproductive health and offspring development.
Read also: Thailand’s Cannabis & Hemp Market Poised to Reach ฿43 Billion by 2025
Impact on Offspring Development
Studies have shown that prenatal cannabis exposure may lead to several health issues in newborns, including:
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Lower infant birth weight
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Higher chances of neonatal intensive care (NICU) admission
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Altered immune system development
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Increased risk of neurodevelopmental disorders
As cannabis potency continues to rise — from 4% THC in the past to over 30% today — these potential risks demand deeper scientific investigation.
Cannabis and Sperm DNA Alteration
Researchers from Duke University discovered that cannabis use can influence sperm DNA methylation, a process that regulates gene expression.
Key findings include:
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Reduced sperm concentration in THC-exposed males
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Changes in epigenetic markers that may pass to offspring
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Alterations in 46 critical genes, including those linked to brain development
DLGAP2 Gene and Neurological Impact
One significant discovery involved the DLGAP2 gene, which plays a vital role in neuronal signaling and synapse organization.
Alterations in this gene were linked to:
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Learning disabilities
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Abnormal social behavior
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Increased aggression
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Higher risks of autism and schizophrenia
This suggests that cannabis-related DNA changes may have long-term neurological consequences for future generations.
What This Means for Health and Fertility
While cannabis legalization continues, these findings highlight the need for responsible usage — especially among men planning for parenthood.
Key takeaways:
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Cannabis may impact sperm quality and DNA integrity
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Epigenetic changes could affect future children’s health
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More clinical research is needed to understand long-term effects
Bicaro Holding’s Perspective
At Bicaro Holding, we believe in responsible cannabis cultivation and scientific research to unlock its benefits while understanding its risks. As the cannabis industry evolves, education and awareness remain essential for both consumers and investors.